Replacement of recipient hematopoiesis

Replacement of recipient hematopoiesis refers to the clinical procedure that eliminates the patient's native blood-forming system, most often through chemo- or radiotherapy, and then introduces hematopoietic stem cells—typically from a donor—to restore blood cell production and immune function. This is primarily done to treat malignant and nonmalignant disorders of the blood or immune system, such as leukemia, lymphomas, and immune deficiencies. The process involves complex risks, especially graft-versus-host disease and infection, and requires close monitoring for engraftment and complications. It is not a molecular or receptor target, but a procedural therapeutic approach involving the transplantation of hematopoietic stem and progenitor cells[1][4][6].

Other names

Hematopoietic stem cell transplantationHematopoietic system replacementBlood cell system replacement

Induction of donor cell engraftment; Replacement of blood and immune cells by donor hematopoietic stem cells[1][4]