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Target intelligence / Profile preview
Replication factor C subunit 2 (RFC2)
- Target
- RFC2
- Molecular classification
- Other (Replication complex component), Enzyme (ATPase activity)
01
Overview
Replication factor C subunit 2 (RFC2) is a 40 kDa protein that forms part of the heteropentameric replication factor C (RFC) complex, also known as activator 1, which is essential for the elongation of primed DNA templates during DNA replication and repair[1][2][4][5]. RFC2 binds ATP and is critical for loading the proliferating cell nuclear antigen (PCNA) onto DNA[1][2][4]. Disruption of RFC2 has been linked to Williams syndrome[1][2][5]. Dysregulation of RFC2 is associated with malignant progression in various cancers, where it serves as a prognostic biomarker and influences tumor mutational burden, microsatellite instability, and immune infiltration[2][3]. RFC2 interacts with proteins including PCNA, BRD4, CHTF18, RFC4, and RFC5, but it is not currently targeted by any approved drugs[1][2][4].
- Other names
- RFC40A1 40 kDa subunitActivator 1 subunit 2RF-C 40 kDa subunitReplication factor C 40 kDa subunitActivator 1 40 kDa subunit
02
Biological functions
DNA replicationDNA repairDNA recombinationATP bindingCell survival
03
Disease associations
Cancer (prognostic biomarker, oncogenic driver in some cancers)Genetic disorder (Williams syndrome due to gene deletion)
04
Safety considerations
Overexpression associated with tumor progression and poor prognosis in several cancers
05
Biomarkers
Prognostic biomarker in low-grade glioma, hepatocellular carcinoma, colorectal carcinoma, gastric cancer
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