Replication factor C subunit 2 pseudogene

Replication factor C subunit 2 pseudogene is a non-coding DNA sequence in the human genome with high sequence similarity to the protein-coding **RFC2** gene, which encodes a 40 kDa subunit of replication factor C, an essential protein complex involved in DNA replication and repair. Pseudogenes such as this do not encode functional proteins and typically lack established biological functions. They are not considered therapeutic targets, enzymes, receptors, or transporters[7]. Some pseudogenes may regulate gene expression through mechanisms like competing endogenous RNA or microRNA sponging, but there is no evidence supporting such functions for this RFC2 pseudogene[7]. Accordingly, it does not have known interacting drugs, biomarker potential, or disease implications.\n\n**Key context:**\n- This entry is **not a valid therapeutic target**. The confusion may stem from its similarity to the true RFC2 gene, which is protein-coding and functionally relevant to DNA replication[1][3].\n- Pseudogenes are generally classified as "Other" in molecular taxonomy since they are non-coding and are not grouped with enzymes, receptors, or similar families[7].\n- There is no literature evidence that this particular pseudogene (ENSG00000224529 / LOC100533727) encodes a protein, has a role in disease, or is druggable or actionable in the sense of therapeutic intervention.\n\n**If you are seeking information on the functional RFC2 gene**, the appropriate canonical name would be "Replication factor C subunit 2", which codes for the 40 kDa subunit of the clamp loader complex essential for DNA replication and repair[1][3][5]. If you need datasheets for the protein-coding RFC2, request information for the gene identifier ENSG00000049541 or UniProt P35250.

Other names

Replication factor C (activator 1) 2, 40kDa pseudogeneLOC100533727RFC2 pseudogene