Replication termination factor 2 (RTF2)

Replication termination factor 2 is a DNA replication regulatory protein and component of the elongating replisome. It facilitates the localization of the Ribonuclease H2 complex to replication forks, supports normal removal of aberrant ribonucleotides, and ensures efficient DNA replication completion. Under conditions of replication stress, RTF2 is proteasomally removed to enable replication restart. RTF2 plays a vital role in triggering ATR-dependent checkpoint signaling and maintaining genome stability. Deficiency or dysregulation of RTF2 leads to replication fork processing defects, abnormal S/G2 transition, and increased risk for genome instability. Beyond its replication roles, RTF2 restricts influenza virus transcription within the nucleus, acting as an interferon-stimulated antiviral factor. Diseases genetically associated with RTF2 include Amyotrophic Lateral Sclerosis 7 and fungal infection (Trichosporonosis), with emerging evidence of its involvement in cancer through DNA damage response and cell cycle regulation.

Other names

C20orf43RTFDC1AD-007CDA05HSPC164HSPC169CDAO5SHUJUN-3replication termination factor 2 domain-containing protein 1UPF0549 protein C20orf43protein RTF2 homologreplication termination factor 2 domain containing 1

For antiviral activity: restriction of viral nuclear transcription and enhancement of interferon-stimulated gene responses. For replication stress: regulation of proteasome-mediated removal, control of fork restart and signaling through ATR.