Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
DNA Polymerase Catalytic Subunit (DNA Pol catalytic subunit)
- Target
- DNA Pol catalytic subunit
- Molecular classification
- Enzyme, Polymerase
01
Overview
The DNA polymerase catalytic subunit is the core enzymatic component of DNA polymerases, responsible for synthesizing new DNA strands from deoxyribonucleotides during replication and repair. It typically contains palm, finger, and thumb domains, and requires divalent metal ions for catalysis. Different catalytic subunits (e.g., alpha, delta, epsilon) have distinct roles in DNA replication and repair, with some possessing proofreading activity.
- Other names
- POLA1POLD1DNA polymerase alpha catalytic subunitDNA polymerase delta catalytic subunitReplicative DNA polymerase
02
Mechanism of action
Template-dependent DNA synthesis
03
Biological functions
DNA replicationDNA repairGenome maintenanceProofreading
04
Disease associations
CancerGenomic instability syndromes
05
Safety considerations
GenotoxicityOff-target effects leading to mutations
Beyond the preview
Go deeper on DNA Polymerase Catalytic Subunit (DNA Pol catalytic subunit).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on DNA Polymerase Catalytic Subunit (DNA Pol catalytic subunit).