Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Repulsive Guidance Molecule A (RGMa)
- Target
- RGMa
- Molecular classification
- Repulsive Guidance Molecule, GPI-linked membrane protein, BMP co-receptor
01
Overview
Repulsive guidance molecule A (RGMa) is a glycosylphosphatidylinositol (GPI)-anchored cell membrane protein and a member of the repulsive guidance molecule family. It acts as a chemorepellent to steer neuronal growth cones during neural development and also modulates immune cell migration. Dysregulation of RGMa is implicated in several CNS disorders, making it a potential therapeutic target for neurodegenerative diseases and injury recovery strategies. RGMa binds to neogenin and functions as a BMP co-receptor.
- Other names
- RGM-ARepulsive guidance molecule BMP co-receptor aRGM domain family member A
02
Mechanism of action
Inhibition of RGMa can enhance CNS repair/regeneration post-injury or disease insult. Blocks growth cone collapse and leukocyte migration.
03
Biological functions
Axon guidanceNeural tube closureCell adhesionCell migrationCell differentiationLeukocyte migration inhibitionBMP signaling regulation
04
Disease associations
Multiple sclerosisNeuromyelitis optica spectrum disordersCerebral infarction/stroke recovery impairmentSpinal cord injuryParkinson’s diseaseEpilepsyCancer
Beyond the preview
Go deeper on Repulsive Guidance Molecule A (RGMa).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Repulsive Guidance Molecule A (RGMa).