Required for meiotic nuclear division 5 homolog A (RMND5A)

Required for meiotic nuclear division 5 homolog A (RMND5A) is an enzyme functioning as an E3 ubiquitin ligase and is a core component of the CTLH E3 ubiquitin-protein ligase complex, selectively accepting ubiquitin from E2 enzymes and catalyzing the ubiquitination and proteasomal degradation of substrate proteins[1][2][3][5]. RMND5A is essential for the catalytic activity of the CTLH complex and interacts with multiple partners within this complex to maintain its stability and activity[2][3]. It has documented roles in cell migration and tumor metastasis, especially in cancer cell models where its overexpression correlates with increased cell migration and poor prognosis, notably in pancreatic adenocarcinoma[1]. RMND5A is also involved in neural development, as demonstrated in non-human models, and has been implicated in rare neurodevelopmental defects when duplicated[4]. The gene's expression and function are regulated post-transcriptionally by various microRNAs, such as miR-590-5p, which can inhibit its promigratory effects in cancer cells[1]. No therapeutic drugs are currently known to target RMND5A directly, but its expression can serve as a prognostic biomarker in certain cancers[1].

Other names

E3 ubiquitin-protein transferase RMND5AFLJ13910RMD5GID2GID2Ap44CTLHProtein RMD5 homolog AGID complex subunit 2 homolog A44-kD protein coding for CTLH motifCTLHC-terminal to LisH motifprotein RMD5 homolog A

Not directly targeted by any drug; mechanistic modulation in studies is through genetic or RNA interference (e.g., targeted by specific microRNAs such as miR-590-5p, miR-21, miR-138)[1][4].