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Resistant Angiogenesis (N/A)
- Target
- N/A
- Molecular classification
- Multifactorial biological process, Network of signaling pathways
01
Overview
Resistant angiogenesis describes the phenomenon where tumors continue to form new blood vessels despite anti-angiogenic therapies. Resistance can be intrinsic (pre-existing) or adaptive (acquired), involving activation of alternative pro-angiogenic pathways (FGF, PDGF, Angiopoietins), recruitment of bone marrow-derived cells, increased pericyte coverage, or vascular co-option. Understanding resistance mechanisms is crucial for developing more effective cancer treatments.
- Other names
- Anti-angiogenic therapy resistanceEvasive resistance to anti-angiogenicsTumor angiogenesis escape
02
Mechanism of action
N/A - Resistance is a process, not a single mechanism
03
Biological functions
NeovascularizationTumor growthMetastasisAdaptive response to therapy
04
Disease associations
CancerAge-related macular degenerationDiabetic retinopathyOther angiogenesis-dependent diseases
05
Safety considerations
Disease progressionIncreased metastasisLack of therapeutic efficacyPotential for paradoxical effects
06
Interacting drugs
VEGF inhibitors (e.g., Bevacizumab, Sunitinib, Sorafenib)
4 more in the full profile.
07
Biomarkers
Increased levels of alternative pro-angiogenic factors (e.g., FGF, PDGF)Changes in tumor microenvironmentIncreased pericyte coveragePresence of circulating endothelial progenitor cells
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