Respiratory epithelial cell membrane

The respiratory epithelial cell membrane is a complex lipid bilayer that serves as the primary interface between the inhaled environment and the pulmonary parenchyma. It plays a fundamental role in maintaining lung homeostasis through the regulation of ion transport, which determines the hydration of the airway surface liquid, and by acting as a physical and immunological barrier against pathogens and pollutants [1, 2]. This membrane contains a diverse array of specialized proteins, including ion channels like the cystic fibrosis transmembrane conductance regulator (CFTR) and various G protein-coupled receptors that regulate bronchodilation and inflammation [3, 5]. In diseases such as asthma, COPD, and cystic fibrosis, the integrity and function of this membrane are often compromised, leading to impaired mucociliary clearance and chronic inflammation [4, 5]. Pharmacological intervention typically involves targeting specific receptors or channels embedded within this membrane to restore physiological function or prevent viral entry [3]. Sources: [1] Ganesan, S., et al. (2013). Am J Respir Crit Care Med. [2] Hollenhorst, M. I., et al. (2011). J Gen Physiol. [3] Vareille, M., et al. (2011). Clin Microbiol Rev. [4] Whitsett, J. A., & Alenghat, T. (2015). Nat Immunol. [5] Heijink, I. H., et al. (2012). Chest.

Other names

Airway epithelial cell membraneBronchial epithelial membranePulmonary epithelial cell membraneRespiratory mucosal surface

Drugs typically target specific integral membrane proteins such as G protein-coupled receptors (GPCRs), ion channels, or transporters located within the respiratory epithelial cell membrane to modulate airway tone, mucus secretion, or inflammatory responses [3, 5].