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Target intelligence / Profile preview
Respiratory Syncytial Virus (RSV) attachment glycoprotein G, subtype A (RSV-A G protein)
- Target
- RSV-A G protein
- Molecular classification
- Viral Glycoprotein, Type II transmembrane glycoprotein, Attachment protein
01
Overview
The Respiratory Syncytial Virus (RSV) attachment glycoprotein G, subtype A, is a major surface protein of RSV that mediates initial attachment of the virus to host cell membranes. It interacts with cellular receptors such as heparan sulfate proteoglycans (HSPG) or CX3CR1. It also modulates the immune response. It is a target for vaccine development and antibody characterization.
- Other names
- RSV G proteinRSV attachment protein GGlycoprotein GAttachment glycoprotein G
02
Mechanism of action
Attachment to host cell receptors (Heparan sulfate proteoglycans (HSPG) or CX3CR1) to mediate viral entry.
03
Biological functions
Viral attachmentHost cell entryImmune modulationReceptor binding
04
Disease associations
InfectionRespiratory Syncytial Virus InfectionBronchiolitisPneumonia
05
Safety considerations
Antigenic variation (subtypes A and B)Potential for immune evasion
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