Respiratory Syncytial Virus F Glycoprotein (Prefusion Conformation) (RSV F (preF))

The respiratory syncytial virus prefusion-F glycoprotein is an essential viral surface protein responsible for mediating entry into host cells through direct membrane fusion. Its metastable trimeric structure presents unique antigenic surfaces that elicit robust neutralizing antibody responses during natural infection—making it an optimal target for vaccine design. Stabilized versions capturing this conformation underpin current advances in effective prophylactic strategies against severe RSV disease across age groups.

Other names

RSV Fusion glycoproteinF protein (prefusion)PreFRSV F protein

Neutralizing antibody binding to preF conformation, blocking membrane fusion