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Target intelligence / Profile preview
Respiratory Syncytial Virus Glycoprotein (RSV Glycoprotein)
- Target
- RSV Glycoprotein
- Molecular classification
- Viral envelope glycoprotein, Type II transmembrane glycoprotein (G protein), Class I viral fusion protein (F protein)
01
Overview
Respiratory syncytial virus (RSV) possesses two major surface glycoproteins critical for its infectivity: the attachment glycoprotein (G) and the fusion glycoprotein (F). These proteins mediate the initial steps of viral infection, including host cell recognition, attachment, and membrane fusion. The G protein binds to heparan sulfate and CX3CR1 to attach to host cells and modulate immune responses. The F protein mediates the fusion of the viral envelope with the target cell membrane. Both proteins are major targets for neutralizing antibodies and vaccine development.
- Other names
- RSV G proteinRSV F proteinAttachment Glycoprotein (G)Fusion Glycoprotein (F)
02
Mechanism of action
Neutralizing antibodies block viral attachment (G protein) or membrane fusion (F protein). Antiviral drugs inhibit F protein function.
03
Biological functions
Viral attachmentMembrane fusionHost cell entryImmune modulation
04
Disease associations
InfectionRespiratory disease
05
Safety considerations
Potential for antibody-dependent enhancement (ADE) of diseaseEliciting broadly neutralizing antibodies
06
Interacting drugs
Neutralizing antibodies
1 more in the full profile.
07
Biomarkers
Antibody titers against G and F proteins
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