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Target intelligence / Profile preview
Respiratory Syncytial Virus Glycoprotein F (RSV F)
- Target
- RSV F
- Molecular classification
- Viral fusion protein, Type I integral membrane protein, Glycoprotein
01
Overview
The respiratory syncytial virus (RSV) glycoprotein F, commonly referred to as the fusion (F) protein, is a type I integral membrane protein found on the surface of RSV virions. It plays a central role in viral entry by mediating the fusion of the viral envelope with host cell membranes, allowing viral RNA to enter target cells. The mature RSV F glycoprotein is organized as a homotrimer composed of three non-covalently associated protomers, each consisting of an F1 and an F2 subunit. RSV F exists in two major conformations: pre-fusion and post-fusion. It is a major antigen recognized by neutralizing antibodies and an important target for antiviral drug development against RSV.
- Other names
- Fusion glycoproteinF proteinRSV fusion protein
02
Mechanism of action
Neutralizing antibody; blocks RSV F-mediated membrane fusion
03
Biological functions
Membrane fusionViral entryHost cell attachmentReceptor binding
04
Disease associations
InfectionRespiratory diseaseBronchiolitisPneumonia
05
Safety considerations
Antibody resistanceImmunogenicity
06
Interacting drugs
Palivizumab
1 more in the full profile.
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