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Respiratory Syncytial Virus M2-1 Protein (M2-1)

Target: M2-1
Molecular classification: Transcription factor

Overview

The M2-1 protein is an essential regulatory protein encoded by the human respiratory syncytial virus (RSV). It functions primarily as a transcriptional processivity and antitermination factor within the viral RNA polymerase complex, enabling synthesis of full-length viral mRNAs. It forms a stable tetrameric assembly, and contains an N-terminal Cys3His1 zinc-finger motif essential for structural integrity and activity. It interacts with viral phosphoprotein P, nucleocapsid protein N, and matrix protein M.

Mechanism of action

Inhibition of M2-1 function (transcription elongation/antitermination)

Biological functions

Transcription elongationAntitermination

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Infection

Interacting drugs

Quercetin

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