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Target intelligence / Profile preview
Respiratory Syncytial Virus Matrix Protein M2–1 (M2-1)
- Target
- M2-1
- Molecular classification
- Transcription factor
01
Overview
The M2-1 protein is a critical regulatory protein encoded by the human respiratory syncytial virus (HRSV). It acts as a transcriptional processivity and antitermination factor essential for viral gene expression. It prevents premature termination during transcription by binding competitively to both viral RNA and the phosphoprotein (P). It also enhances readthrough of intergenic junctions during viral mRNA synthesis, allowing production of full-length or polycistronic RNAs. Due to its essential role in RSV replication/transcription—and absence from host cells—M2–1 represents an attractive antiviral drug target.
- Other names
- Transcription antitermination factor M2–1Envelope-associated 22 kDa proteinVp24
02
Mechanism of action
Inhibition of M2-1 activity
03
Biological functions
Transcription processivityTranscription antiterminationViral mRNA synthesisVirion assembly
04
Disease associations
Infection
05
Interacting drugs
Quercetin
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