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Target intelligence / Profile preview
Respiratory Syncytial Virus Nucleocapsid Protein (N)
- Target
- N
- Molecular classification
- Viral protein, Structural protein, RNA-binding protein
01
Overview
The nucleocapsid protein (N) of respiratory syncytial virus (RSV) is a highly conserved, multifunctional structural protein essential for the virus's life cycle. It encapsidates the viral negative-sense RNA genome, forming a left-handed helical nucleocapsid that protects the RNA from degradation and serves as a template for both mRNA synthesis and genome replication. The RSV N protein is considered an attractive antiviral drug target due to its conservation across strains and central role in multiple stages of infection.
- Other names
- RSV N proteinRSV nucleoprotein
02
Mechanism of action
Inhibition of nucleocapsid protein function, interference with encapsidation or RNP formation
03
Biological functions
Genome encapsulationTemplate for viral mRNA transcriptionTemplate for viral genome replicationVirus assembly
04
Disease associations
Infection
05
Interacting drugs
RSV604
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