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Target intelligence / Profile preview
Respiratory Syncytial Virus Polymerase (RSV Polymerase)
- Target
- RSV Polymerase
- Molecular classification
- Enzyme, RNA-dependent RNA polymerase, Viral protein complex
01
Overview
The respiratory syncytial virus (RSV) polymerase is a multifunctional enzyme complex essential for RSV genome replication and transcription. It is composed primarily of two proteins: the large (L) protein, which serves as the RNA-dependent RNA polymerase (RdRp), and the tetrameric phosphoprotein (P), which acts as an essential cofactor. The polymerase complex binds to the viral genomic RNA at specific promoter sites to initiate either genome replication or mRNA synthesis. Inhibitors targeting various functions within this complex are under clinical development.
- Other names
- RSV L-P complexRSV RNA-dependent RNA polymerase
02
Mechanism of action
Inhibition of RNA synthesis, Inhibition of mRNA capping, Inhibition of mRNA methylation
03
Biological functions
RNA synthesisGenome replicationmRNA transcriptionmRNA cappingmRNA methylation
04
Disease associations
InfectionRespiratory Syncytial Virus Infection
05
Safety considerations
Potential for drug resistance due to mutations in the polymerase gene
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