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Target intelligence / Profile preview
REST Corepressor 1 (RCOR1)
- Target
- RCOR1
- Molecular classification
- Transcription factor, Chromatin binding, DNA-binding transcription repressor
01
Overview
REST Corepressor 1 (CoREST) is a transcriptional corepressor that plays a critical role in neural cell differentiation. In complex with REST, CoREST recruits chromatin-modifying enzymes, inducing chromatin condensation and transcriptional repression. It is essential for regulating neurogenesis by repressing neuronal gene expression in non-neuronal cells during development. Mutations or dysregulation involving RCOR1 have been associated with diseases including Joubert Syndrome 1 and medulloblastoma.
- Other names
- CoRESTCoREST1
02
Mechanism of action
Transcriptional repression via recruitment of chromatin-modifying enzymes (LSD1/KDM1A, HDAC1/2, G9a, BRG1) leading to chromatin condensation.
03
Biological functions
Transcriptional corepressionRegulation of neurogenesisChromatin modification
04
Disease associations
Joubert Syndrome IMedulloblastoma
05
Safety considerations
Dysregulation can lead to increased neural progenitor proliferation at the expense of neuronal and oligodendrocyte differentiation.
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