REST corepressor 3 (RCOR3)

REST corepressor 3 is a chromatin-associated protein that functions as a transcriptional corepressor together with REST and complementary chromatin-modifying enzymes, including histone deacetylases and lysine-specific demethylases. It is mainly located in the cytosol and nucleoplasm and modulates gene expression through chromatin condensation, resulting in the suppression of neuronal and other cell-type-specific genes. RCOR3 can operate both in REST-dependent and REST-independent mechanisms, suggesting independent regulatory roles in neurodevelopment and disease processes. Its expression and activity have been linked to disease prognosis in hepatitis B and have potential relevance for other disorders characterized by aberrant gene repression.

Other names

RCOR3KIAA1343FLJ10876REST corepressor 3

Drugs that target chromatin-modifying enzymes (such as HDAC inhibitors or LSD1 inhibitors) may influence RCOR3 function indirectly, as it forms complexes with these enzymes but no direct RCOR3-specific drugs are described