Resveratrol

Resveratrol is a naturally occurring polyphenolic compound found in various plants such as grapes, berries, peanuts, and Japanese knotweed. It exists mainly in two forms—cis-(Z) and trans-(E)—with the trans form being more biologically active. Resveratrol has attracted significant scientific interest because of its broad spectrum of biological activities including antioxidant, anti-inflammatory, antiapoptotic effects, modulation of cell signaling pathways like SIRT1/AMPK/Nrf2/MAPK/PTEN/Akt/mTOR/TNF-related apoptosis-inducing ligand (TRAIL), among others. It has been studied for potential benefits against cancer, cardiovascular diseases, diabetes/metabolic syndrome, neurodegenerative conditions like Alzheimer's disease, respiratory illnesses including pulmonary fibrosis and interstitial lung diseases. Despite promising preclinical data suggesting chemopreventive properties against cancer and cardiovascular protection via inhibition of oxidative metabolism enzymes involved in carcinogen activation, clinical translation remains limited by poor oral bioavailability due to rapid metabolism. Safety concerns are generally low at dietary intake levels but may arise with pharmacological dosing regimens. Resveratrol should not be listed as a therapeutic target—it is instead an agent/drug/small molecule that modulates many true molecular targets within cells. If you seek information about one specific protein targeted by resveratrol—such as SIRT1 ("Sirtuin [NAD-dependent deacetylase]")—that would be considered the actual therapeutic target rather than resveratrol itself.

Other names

3,5,4'-trihydroxystilbenetrans-resveratrol(E)-resveratrolSRT501

As an activator of sirtuin proteins such as SIRT1 ("Sirtuin activator"). Modulates AMPK/SIRT1/Nrf2 signaling pathways to promote antioxidant gene expression and mitochondrial biogenesis. Inhibits inflammatory mediators via NF-kB pathway suppression. Induces apoptosis in cancer cells through p53 activation and mitochondrial pathways. These mechanisms describe how resveratrol acts on biological systems rather than how something would act upon "resveratrol" itself.