Ret finger protein-like 4A-like protein 1 (RFPL4AL1)

Ret finger protein-like 4A-like protein 1 (RFPL4AL1) is a predicted E3 ubiquitin-protein ligase encoded by the human *RFPL4AL1* gene on chromosome 19. It is predicted to participate in ubiquitin-mediated protein degradation, the regulation of transcription, positive regulation of canonical NF-kappaB signal transduction, autophagy, regulation of gene expression, and may play a role in the innate immune response. Its predicted cellular locations are the cytosol and nucleoplasm. There is no evidence from the biomedical literature or drug databases that RFPL4AL1 is an established therapeutic target, nor that it is involved in common therapeutic pathways. The gene is associated with "Photoparoxysmal Response 1," although a functional or mechanistic connection has not been rigorously established. No drugs, clinical biomarkers, or validated mechanisms of action have been identified for this protein to date[1][2][5][7][8].

Other names

RNF210Bret finger protein like 4A like 1ret finger protein-like 4A-like protein 1