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Target intelligence / Profile preview
Ret finger protein-like 4B (RFPL4B)
- Target
- RFPL4B
- Molecular classification
- Other, RING finger protein, E3 ubiquitin-protein ligase
01
Overview
**Ret finger protein-like 4B (RFPL4B)** is a protein encoded by the RFPL4B gene in humans, located on chromosome 6. It is a member of the RING finger protein family and is predicted to function as an E3 ubiquitin-protein ligase, mediating protein ubiquitination. Biological functions associated with RFPL4B include involvement in the innate immune response, negative regulation of viral entry and viral transcription, as well as regulation of gene expression. No well-established roles as a therapeutic drug target, interacting drugs, or use as a biomarker have been documented. Disease associations reported in databases are restricted to muscular dystrophies, but mechanistic involvement remains not well established.
- Other names
- RFPL4BRNF211RING finger protein 211ret finger protein like 4Bret finger protein-like 4B
02
Biological functions
Ubiquitin protein ligase activityinnate immune responseregulation of gene expressionmetal ion bindingdefense response to symbiontnegative regulation of viral entry into host cellnegative regulation of viral transcription
03
Disease associations
Facioscapulohumeral Muscular Dystrophy 1Facioscapulohumeral Muscular Dystrophy 2Digenicpossible roles in immune response
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