Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
RET proto-oncogene (Rearranged during Transfection) (RET)
- Target
- RET
- Molecular classification
- Receptor tyrosine kinase, Receptor
01
Overview
RET (Rearranged during Transfection) is a receptor tyrosine kinase that plays a crucial role in neural crest development, kidney morphogenesis, and spermatogenesis. It requires GFRα co-receptors for activation by GDNF family ligands. RET activates downstream signaling pathways including MAPK/ERK, PI3K/AKT, and STAT3, influencing cell proliferation, differentiation, survival, and migration. Mutations in RET are associated with various diseases, including Hirschsprung's disease (loss-of-function) and multiple endocrine neoplasia and certain cancers (gain-of-function). It is a validated drug target for RET-altered cancers.
- Other names
- Rearranged during Transfection proto-oncogeneCDHF12MEN2AMEN2BMTC1PTC2RET51RET43RET9
02
Mechanism of action
Small molecule inhibitors targeting the RET kinase domain, preventing autophosphorylation and downstream signaling.
03
Biological functions
Signal transductionCell proliferationCell differentiationCell survivalCell migrationNeurogenesisKidney developmentSpermatogenesis
04
Disease associations
Hirschsprung's diseaseMultiple endocrine neoplasia type 2A (MEN2A)Multiple endocrine neoplasia type 2B (MEN2B)Papillary thyroid carcinomaPheochromocytomaParathyroid hyperplasiaNon-small cell lung cancerCancer
05
Safety considerations
HypertensionQT prolongationHemorrhageWound healing complicationsHypocalcemiaDiarrheaFatigueDrug-drug interactions
06
Interacting drugs
Selpercatinib
3 more in the full profile.
07
Biomarkers
RET mutations (e.g., M918T, C634W) in tumor tissueRET fusions (e.g., KIF5B-RET, CCDC6-RET) in tumor tissueRET protein expression levels
Beyond the preview
Go deeper on RET proto-oncogene (Rearranged during Transfection) (RET).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on RET proto-oncogene (Rearranged during Transfection) (RET).