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Target intelligence / Profile preview
RET Proto-oncogene Protein (RET)
- Target
- RET
- Molecular classification
- Receptor Tyrosine Kinase
01
Overview
The RET proto-oncogene encodes a receptor tyrosine kinase essential for neural crest-derived cell development, urogenital system formation, and nervous system development. It acts as a receptor for GDNF family ligands, requiring GFRα co-receptors. RET activation triggers MAPK, PI3K/AKT, and JAK/STAT pathways, regulating gene expression related to growth, survival, migration, and differentiation. Mutations in RET are associated with developmental disorders like Hirschsprung's disease and cancers such as multiple endocrine neoplasia and thyroid carcinoma, making it a therapeutic target for selective small-molecule inhibitors.
- Other names
- Rearranged during Transfection
02
Mechanism of action
Inhibition of RET kinase activity
03
Biological functions
Cell proliferationNeuronal navigationCell migrationDifferentiationSurvivalSignal transduction
04
Disease associations
Hirschsprung's diseaseMultiple endocrine neoplasia type IIa/b (MEN IIa/b)Medullary thyroid carcinomaPapillary thyroid carcinomaPheochromocytomaParathyroid hyperplasiaCancer
05
Safety considerations
Potential for off-target effects of RET inhibitorsResistance development to RET inhibitors
06
Interacting drugs
Selective small-molecule inhibitors targeting RET
07
Biomarkers
RET mutations (e.g., M918T)RET fusions/rearrangements
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