Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
RET Proto-oncogene Tyrosine-Protein Kinase (RET)
- Target
- RET
- Molecular classification
- Receptor Tyrosine Kinase, Enzyme
01
Overview
The human *RET* proto-oncogene encodes a unique receptor tyrosine kinase crucial for neural development but also implicated in several aggressive cancers when mutated or rearranged. Its complex activation mechanism involves both ligand binding from the GDNF family and interaction with specific coreceptors—a feature distinguishing it from many other RTKs. Both loss-of-function mutations leading to developmental disorders like Hirschsprung disease and gain-of-function mutations driving oncogenesis highlight its clinical significance as a therapeutic target.
- Other names
- Rearranged during TransfectionRET51RET9
02
Mechanism of action
Inhibition of RET tyrosine kinase activity, blocking downstream signaling pathways (RAS-MAPK/ERK1/2, PI3K-AKT)
03
Biological functions
Cell proliferationCell differentiationCell migrationCell survivalNeural developmentAppetite regulationWeight controlSignal transduction
04
Disease associations
Hirschsprung diseaseMultiple endocrine neoplasia type 2AMultiple endocrine neoplasia type 2BMedullary thyroid carcinomaPheochromocytomaPapillary thyroid carcinomaLung cancerColorectal cancerBreast cancerCentral hypoventilation syndromeRenal agenesis
05
Safety considerations
Off-target effects of multikinase inhibitorsDevelopment of resistance to RET inhibitors
06
Interacting drugs
Small-molecule multikinase inhibitors with anti-RET activity
1 more in the full profile.
07
Biomarkers
RET mutations in tumor tissueRET fusion transcripts in tumor tissue
Beyond the preview
Go deeper on RET Proto-oncogene Tyrosine-Protein Kinase (RET).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on RET Proto-oncogene Tyrosine-Protein Kinase (RET).