Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
RET Proto-oncogene Tyrosine-Protein Kinase Receptor (RET)
- Target
- RET
- Molecular classification
- Receptor, Receptor tyrosine kinase, Transmembrane receptor
01
Overview
The RET proto-oncogene encodes a transmembrane receptor tyrosine kinase that is primarily involved in signaling pathways regulating cell proliferation, differentiation, migration, and survival. It is especially important for the development of the nervous system and organs derived from the neural crest.
- Other names
- MEN2AMEN2BHirschsprung diseaseRET51RET9
02
Mechanism of action
Inhibition of RET kinase activity
03
Biological functions
Cell proliferationCell differentiationCell migrationCell survivalSignal transductionDevelopment of nervous systemOrganogenesisAppetite regulationWeight control
04
Disease associations
CancerPapillary thyroid carcinomaMedullary thyroid carcinoma (MTC)Multiple endocrine neoplasia type IIPheochromocytomaParathyroid hyperplasiaHirschsprung's diseaseCentral hypoventilation syndromeRenal agenesis
05
Safety considerations
Specific toxicities associated with kinase inhibitorsResistance development
06
Interacting drugs
Small molecule inhibitors targeting RET
07
Biomarkers
RET mutations (e.g., M918T)RET/PTC fusion
Beyond the preview
Go deeper on RET Proto-oncogene Tyrosine-Protein Kinase Receptor (RET).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on RET Proto-oncogene Tyrosine-Protein Kinase Receptor (RET).