Retention in endoplasmic reticulum sorting receptor 1 (RER1)

Retention in endoplasmic reticulum sorting receptor 1 (RER1) is a multi-pass transmembrane sorting receptor primarily localized at the cis-Golgi and intermediate compartment. Its main function is to retrieve escaped endoplasmic reticulum (ER) membrane proteins and unassembled subunits of oligomeric complexes from the cis-Golgi back to the ER, preserving compartmentalization and ensuring proper complex assembly[3][5]. It recognizes specific motifs in the transmembrane domains of substrate proteins, thereby contributing to ER quality control[3][1][4]. RER1 is conserved from yeast (Rer1p) to mammals, and is implicated in neurological processes by influencing γ-secretase assembly and amyloid-β production, linking it to neurodegenerative disease pathways[3]. At present, there are no approved drugs targeting RER1, and it is not categorized as a therapeutic target in clinical practice[3][5].

Other names

Protein RER1RER1 retention in endoplasmic reticulum 1 homologRER1p (yeast ortholog)Retention in endoplasmic reticulum 1

Not applicable (no known drugs directly target RER1)