Reticulocalbin-3 (RCN3)

Reticulocalbin-3 (RCN3) is an endoplasmic reticulum lumenal protein from the CREC family of multiple EF-hand calcium-binding proteins, functioning mainly as a molecular chaperone in the secretory pathway[2][3][7]. It assists in the biosynthesis and transport of select proteins (notably, pulmonary surfactant proteins A and D and the lipid transporter ABCA3) and is essential for maintaining pulmonary function and extracellular matrix homeostasis, particularly through regulation of collagen synthesis and fibrillogenesis[1][3][7]. RCN3 negatively regulates the secretion of type I and III collagens (demonstrating anti-fibrotic activity) and plays a crucial role in postnatal tendon development, affecting tenocyte maturation and collagen architecture[1][3][9]. Its dysfunction is linked to diseases involving fibrosis, neonatal respiratory failure, and certain congenital myopathies[1][3]. No drugs are currently known to directly target or modulate RCN3.

Other names

Reticulocalbin 3RCN3RLP49EF-hand calcium-binding protein RLP49reticulocalbin-3EF-hand calcium binding domainUNQ239/PRO272reticulocabin