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Reticulocyte-binding protein homolog 5 (RH5)
- Target
- RH5
- Molecular classification
- Reticulocyte Binding Protein Homolog, Invasion ligand
01
Overview
Reticulocyte-binding protein homolog 5 (RH5), also known as PfRH5, is a key protein expressed by the malaria parasite *Plasmodium falciparum*. It plays an essential role in the invasion of human erythrocytes (red blood cells) during the blood stage of malaria infection. Unlike other members of its family, RH5 is indispensable for parasite survival and is highly conserved across different *P. falciparum* strains. RH5 functions as an invasion ligand that enables merozoites to enter human erythrocytes through a specific interaction with its host receptor, basigin (CD147), on the surface of red blood cells. Due to its essential function and low sequence diversity, RH5 has become a leading candidate for next-generation blood-stage malaria vaccines.
- Other names
- PfRH5PF3D7_0424100
02
Mechanism of action
Antibody-mediated blocking of RH5-Basigin interaction, preventing erythrocyte invasion
03
Biological functions
Erythrocyte invasionMerozoite attachmentReceptor binding (Basigin/CD147)
04
Disease associations
MalariaInfection
05
Safety considerations
Potential for off-target effects of antibodiesDevelopment of resistance to vaccine-induced immunity
06
Biomarkers
Anti-RH5 antibody levels (predictive of protection against clinical malaria)
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