Reticulon-4 (Nogo-A) (Nogo-A)

Reticulon-4, also known as Nogo-A, is a membrane-associated protein encoded by the RTN4 gene, primarily expressed in the central nervous system. It is the most well-characterized inhibitor of neurite outgrowth, limiting neuronal regeneration and plasticity after injury by interacting with the Nogo receptor (NgR1) complex. Nogo-A contains multiple inhibitory domains, including amino-Nogo and Nogo-66, which restrict axonal growth and contribute to the failure of CNS neurons to regenerate after injury. Besides its role in axonal inhibition, Reticulon-4/Nogo-A participates in the shaping of endoplasmic reticulum membranes and regulates protein folding by interacting with ER-resident proteins such as protein disulfide isomerase. Pathophysiologically, Nogo-A is implicated in neurodegenerative diseases, spinal cord injury, multiple sclerosis, and stroke, making it a significant target for therapeutics aimed at promoting neural regeneration and recovery in the CNS[1][2][3][4][5][6][7].

Other names

Neurite outgrowth inhibitorRTN4NogoNogo proteinReticulon-4A

Inhibition of Nogo-A (for example, by anti-Nogo-A antibodies) neutralizes its axon growth-inhibiting effects, potentially promoting neural regeneration and functional recovery after CNS injury[1][3].