Reticulophagy regulator 1 (RETREG1)

Reticulophagy regulator 1 (RETREG1, also known as FAM134B) is an endoplasmic reticulum (ER)-anchored membrane protein and the first identified ER-phagy receptor. It mediates selective autophagy of the ER ("reticulophagy") by binding to LC3/GABARAP proteins through its LC3-interacting region (LIR) and promoting fragmentation of the ER membrane via its reticulon-homology domain (RHD)[2][5][7]. RETREG1 is essential for maintaining ER homeostasis, protein quality control, and long-term survival of sensory and autonomic neurons. Mutations result in hereditary sensory and autonomic neuropathy type IIB (HSAN2B), characterized by profound sensory loss. RETREG1 also plays roles in cancer (both oncogenic and tumor-suppressor functions), Golgi organization, viral infection, and inflammatory responses. It is found in the ER, Golgi, and, in some contexts, the nucleus[2][5][7][3][1]. No approved drugs directly target this protein, but its critical role in neurodegeneration and cancer makes it a potential therapeutic target.

Other names

FAM134BJK1JK-1FLJ20152Reticulophagy receptor 1Family with sequence similarity 134 member BProtein FAM134B

Not currently drugged, but mechanism would involve modulation of autophagy/ER-phagy pathways and ER stress responses