Reticulophagy regulator 2 (RETREG2)

Reticulophagy regulator 2 (RETREG2) is a protein anchored in the endoplasmic reticulum (ER) membrane that functions as an ER-phagy receptor, helping regulate selective autophagy of the ER (termed "reticulophagy")[1][2][3][4]. RETREG2 is typically inactive under normal conditions but becomes activated following cellular stress, where it mediates ER fragmentation and facilitates sequestration of ER fragments into autophagosomes for lysosomal degradation through interaction with ATG8 family proteins[1][3][4]. This mechanism is important for maintenance of ER morphology, protein/collagen quality control, and adaptation to stress; dysfunction of RETREG2 has been linked to some forms of hereditary sensory and autonomic neuropathy[1][2][4][7]. Unlike classical drug targets such as receptors or enzymes, RETREG2 is not currently considered a therapeutic target and no drugs are known to directly modulate its function[1][2][3][4].

Other names

C2orf17FAM134AMAG2MGC3035MAG-2family with sequence similarity 134 member Ametastasis associated gene-2protein FAM134A