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Reticulophagy regulator family member 3 (RETREG3)
- Target
- RETREG3
- Molecular classification
- Other (autophagy adaptor protein; not classified as receptor, enzyme, transporter, transcription factor, etc.)
01
Overview
Reticulophagy regulator family member 3 (RETREG3) is an endoplasmic reticulum-anchored protein that functions as an autophagy regulator, predominantly in neurons[1][2]. It localizes to ER tubules and sheet edges, where it interacts with curvature-inducing proteins like RTN4B to modulate ER morphology. RETREG3 is involved in reticulophagy, a process facilitating ER turnover under conditions of cellular stress, promoting ER fragmentation and subsequent autophagic clearance[2]. Its expression is crucial for neuronal differentiation, with roles in neurite outgrowth and axon morphogenesis. Loss of RETREG3 impairs axonal growth and dendrite formation. RETREG3 acts in a protein-containing complex and is found in various neural tissues as well as other organs[1][8][11].
- Other names
- FAM134Creticulophagy regulator 3DKFZp686B1036FLJ33806family with sequence similarity 134 member Cprotein FAM134C1300010M03Rik4933404C01RikGT212RGD1561189
02
Biological functions
Endoplasmic reticulum-autophagosome adaptor activityEndoplasmic reticulum tubular network organizationReticulophagy (a selective autophagy process for ER turnover)Positive regulation of neuron projection development
03
Disease associations
Cortical dysplasia, complex, with other brain malformations 4Neuropathy, hereditary sensory and autonomic, type IIbOther (no strong associations with cancer or major disease areas documented)
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