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Retinal Neovascularization Pathway
- Molecular classification
- Pathway
01
Overview
Retinal neovascularization refers to the abnormal growth of new blood vessels in the retina. This process is central to several blinding eye diseases and involves a complex cascade of molecular and cellular events triggered by retinal ischemia or hypoxia. Key pathways and molecules involved include VEGF, Angiopoietin/Tie2, NFAT, and CHOP-HIF1α. Therapeutic strategies target these components to reduce neovascularization and improve visual outcomes.
- Other names
- Retinal AngiogenesisOcular Neovascularization
02
Mechanism of action
Various, including inhibition of VEGF, modulation of Angiopoietin/Tie2 signaling, inhibition of NFAT, and modulation of ER stress response
03
Biological functions
AngiogenesisVascular remodelingCell proliferationCell migrationInflammation
04
Disease associations
Diabetic RetinopathyRetinopathy of PrematurityAge-related Macular Degeneration (AMD)Other retinal vascular diseases
05
Safety considerations
Systemic anti-VEGF effectsRetinal detachmentEndophthalmitisVascular occlusion
06
Interacting drugs
Ranibizumab
3 more in the full profile.
07
Biomarkers
VEGF levelsAng-2 levelsHIF1α expression
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