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Target intelligence / Profile preview
Retinal Pigment Epithelium (RPE)
- Target
- RPE
- Molecular classification
- Epithelial cells, Tissue
01
Overview
The retinal pigment epithelium (RPE) is a single layer of pigmented, hexagonal epithelial cells located between the neurosensory retina and the underlying choroid. It forms a critical barrier and interface, playing essential roles in supporting photoreceptor function and overall visual health. Its functions include phagocytosis of photoreceptor outer segments, nutrient/waste transport, light absorption, participation in the visual cycle, and barrier formation. Dysfunction or degeneration of RPE underlies many blinding diseases.
- Other names
- stratum pigmentosum retinae
02
Biological functions
PhagocytosisNutrient transportWaste transportLight absorptionVisual cycle supportBarrier functionSecretion of growth factorsMaintenance of extracellular matrix
03
Disease associations
Age-related macular degeneration (AMD)Inherited dystrophies (e.g., Best disease)Retinitis pigmentosa
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