Target intelligence / Profile preview

Physical tamponade of detached retina

Molecular classification
Other
01

Overview

Physical tamponade of detached retina refers to the use of a mechanical agent (such as a gas bubble or silicone oil) or a structural support (such as a scleral buckle) to temporarily or permanently block the passage of fluid through retinal breaks and maintain apposition of the neurosensory retina to the retinal pigment epithelium following retinal detachment. This strategy provides the necessary time for retinopexy (laser or cryotherapy) to create a permanent seal; the choice of agent depends on the type and complexity of the detachment and patient factors. It is a therapeutic procedure, not a molecular or pharmacologic target

Other names
Intraocular tamponadesurgical tamponaderetinal tamponadetamponade agent
02

Mechanism of action

Physical blockage/sealing of retinal breaks by creating a surface tension barrier; not molecular or pharmacological action

03

Biological functions

Other
04

Disease associations

Other
05

Safety considerations

Potential for increased intraocular pressureCataract formationEndophthalmitis (infection)Prolonged poor vision with gases or silicone oilsNeed for subsequent procedures (e.g., removal of silicone oil)Poor visual outcomes if macula detached preoperatively
06

Interacting drugs

Sulfur hexafluoride (SF6)

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