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Target intelligence / Profile preview
Retinaldehyde Binding Protein 1 (RLBP1)
- Target
- RLBP1
- Molecular classification
- Lipocalin, Intracellular Carrier Protein
01
Overview
Retinaldehyde Binding Protein 1 (RLBP1), also known as cellular retinaldehyde-binding protein (CRALBP), is a water-soluble carrier protein essential for the proper function of rod and cone photoreceptors in the retina. It binds and transports 11-cis-retinal and 11-cis-retinol, critical intermediates in the visual cycle, facilitating the enzymatic isomerization of all-trans-retinal to 11-cis-retinal, supporting regeneration of visual pigments necessary for vision. Mutations in RLBP1 cause several autosomal recessive retinal degenerative diseases.
- Other names
- Cellular Retinaldehyde-Binding ProteinCRALBP
02
Mechanism of action
N/A
03
Biological functions
Retinoid bindingRetinoid transportVisual cyclePhotoreceptor maintenanceRegulation of retinoid metabolism
04
Disease associations
Retinitis punctata albescensRetinitis pigmentosaBothnia dystrophyNewfoundland rod-cone dystrophyDiabetic Retinopathy
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