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Target intelligence / Profile preview
Retinoblastoma-associated Protein (pRb)
- Target
- pRb
- Molecular classification
- Pocket proteins, Tumor suppressor protein
01
Overview
The retinoblastoma-associated protein (pRb), encoded by the RB1 gene, is a crucial tumor suppressor protein. It regulates cell cycle progression at the G1/S transition by inhibiting E2F transcription factors. Loss or dysfunction of pRb is implicated in retinoblastoma, osteosarcoma, and other cancers. pRb is phosphorylated by cyclin-dependent kinases (CDKs), which releases E2Fs allowing cell cycle progression. Targeting the RB pathway is a potential therapeutic strategy, but direct targeting is challenging due to pRb's role as a suppressor.
- Other names
- RbRB1
02
Mechanism of action
Indirectly targeted via upstream regulators of phosphorylation; direct targeting challenging due to suppressor function
03
Biological functions
Cell cycle regulationTumor suppressionRegulation of G1/S transitionTranscriptional repressionInhibition of E2F transcription factors
04
Disease associations
RetinoblastomaOsteosarcomaLung cancerBladder cancerMelanomaCancer
05
Safety considerations
Restoration of RB function without causing cell cycle arrest in normal cellsIndirect targeting may have off-target effects
06
Biomarkers
RB1 expression levelRB1 mutation status
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