Retinoblastoma-like protein 2 (RBL2)

Retinoblastoma-like protein 2 (RBL2, also known as p130) is a member of the retinoblastoma (RB) family of proteins and functions primarily as a transcriptional corepressor and regulator of the cell cycle[1][3][6]. RBL2 plays a key role in maintaining chromatin structure, particularly through the recruitment of chromatin-modifying enzymes involved in epigenetic transcriptional repression and stabilization of histone methylation[1][6]. By interacting with cyclins, cyclin-dependent kinases, and E2F transcription factors, RBL2 acts as a potent inhibitor of E2F-mediated transcriptional activation and regulates the transition from the G0/G1 to S-phase of the cell cycle[1][6]. It functions upstream in negative regulation of gene expression and is implicated as a tumor suppressor[1][2]. Pathogenic mutations in RBL2 are associated with a rare neurodevelopmental disorder characterized by intellectual disability, developmental delay, and other neurological features as well as a potential role in the development of certain cancers[2].

Other names

RB transcriptional corepressor like 2RBL2RB2p130RBR-2130 kDa retinoblastoma-associated proteinRetinoblastoma-related protein 2PRB2BRUWAGretinoblastoma-like 2