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Target intelligence / Profile preview
Retinoblastoma Pathway-Deficient Tumor Cell (RB Pathway-Deficient Tumor Cell)
- Target
- RB Pathway-Deficient Tumor Cell
- Molecular classification
- Cell, Tumor Cell
01
Overview
A retinoblastoma pathway-deficient tumor cell is a cancer cell with a disrupted retinoblastoma (RB) tumor suppressor pathway. This deficiency, often due to mutations or loss of the RB1 gene or deregulation of pathway components like cyclin D/CDK4/6 or p16INK4a, leads to uncontrolled cell cycle progression, proliferation, and tumorigenesis. The RB pathway regulates cell cycle, proliferation, differentiation, and apoptosis. RB pathway status (functional vs. deficient) can predict therapy response.
- Other names
- RB pathway deficient cancer cellRB- tumor cellRB1-deficient tumor cell
02
Mechanism of action
N/A
03
Biological functions
Cell proliferation (uncontrolled)TumorigenesisEvading cell cycle controlResistance to apoptosis
04
Disease associations
CancerRetinoblastomaGlioblastomaBreast Cancer
05
Safety considerations
Potential for increased sensitivity to cytotoxic therapies leading to increased side effects.Development of resistance mechanisms.
06
Interacting drugs
CDK4/6 inhibitors
3 more in the full profile.
07
Biomarkers
RB1 expression (loss of)p16^INK4a expression (loss of)Cyclin D/CDK4/6 amplification/overexpression
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