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Target intelligence / Profile preview
Retinoic acid-inducible gene I protein (RIG-I)
- Target
- RIG-I
- Molecular classification
- Pattern recognition receptor, Cytosolic receptor, RNA helicase, DExD/H box RNA helicase
01
Overview
Retinoic acid-inducible gene I protein (RIG-I) is a cytosolic pattern recognition receptor (PRR) that plays a central role in the innate immune response to viral infections. It is encoded by the DDX58 gene and recognizes viral RNA with specific features, triggering downstream signaling cascades that result in type I interferon production and pro-inflammatory cytokine expression. While primarily known for antiviral defense, RIG-I also participates in inflammation regulation, cell proliferation, and apoptosis, suggesting involvement in cancer biology and other non-infectious diseases. Its activity is tightly regulated to prevent inappropriate immune activation, and dysregulation has been linked to autoimmune disorders.
- Other names
- DDX58RIGIRetinoic acid-inducible gene 1 protein
02
Mechanism of action
N/A
03
Biological functions
Innate immune responseAntiviral defenseInflammation regulationApoptosisCell proliferationInterferon productionImmune response
04
Disease associations
Viral infectionsAutoimmune disordersCancerInflammation
05
Safety considerations
Overactivation leading to autoimmune disordersExcessive interferon productionChronic inflammation
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