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Target intelligence / Profile preview
Retinoic Acid Receptor (RAR)
- Target
- RAR
- Molecular classification
- Nuclear receptor, Transcription factor
01
Overview
The retinoic acid receptor (RAR) is a nuclear receptor that functions as a ligand-activated transcription factor. It is activated by retinoic acid and regulates gene expression in development, cell growth, differentiation, and various physiological processes. RARs heterodimerize with RXRs and bind to RAREs to control transcription. They are important drug targets in cancer and metabolic diseases.
- Other names
- RAR-alphaRAR-betaRAR-gammaRARARARBRARG
02
Mechanism of action
Ligand binding induces conformational changes, leading to dissociation of corepressors and recruitment of coactivators, enabling transcriptional activation of target genes.
03
Biological functions
Embryonic developmentCell growthDifferentiationOrganogenesisEpithelial homeostasisSpermatogenesisImmune functionBrain functionGene expression regulation
04
Disease associations
CancerMetabolic diseases
05
Interacting drugs
All-trans retinoic acid
4 more in the full profile.
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