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Target intelligence / Profile preview
Retinoic Acid Receptor Alpha (RAR-α)
- Target
- RAR-α
- Molecular classification
- Nuclear hormone receptor, Transcription factor, Receptor
01
Overview
Retinoic Acid Receptor Alpha (RAR-α) is a nuclear hormone receptor and ligand-activated transcription factor encoded by the RARA gene. It plays a crucial role in regulating gene expression involved in cell differentiation, growth, hematopoiesis, spermatogenesis, and skeletal development. RAR-α heterodimerizes with RXR and binds to RAREs on DNA, modulating transcription in response to retinoid ligands. Aberrant RARA function, particularly through chromosomal translocations in acute promyelocytic leukemia, can disrupt normal cellular processes.
- Other names
- RARANR1B1Nuclear receptor subfamily 1, group B, member 1
02
Mechanism of action
Ligand-dependent transcriptional activation or repression; heterodimerization with RXR; recruitment of coactivators or corepressors.
03
Biological functions
Transcriptional regulationCell differentiationCell growthHematopoiesisSpermatogenesisSkeletal developmentOrganogenesis
04
Disease associations
Acute promyelocytic leukemiaMature T-cell lymphomaAlzheimer disease
05
Safety considerations
Retinoic acid syndrome (differentiation syndrome) in APL treatmentTeratogenicity of retinoids during pregnancyPotential for drug resistance
06
Interacting drugs
All-trans retinoic acid
3 more in the full profile.
07
Biomarkers
RARA fusion transcripts in acute promyelocytic leukemiaRARA expression levels in various cancers
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