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Target intelligence / Profile preview
Retinoic acid receptor gamma (RAR-γ)
- Target
- RAR-γ
- Molecular classification
- Nuclear hormone receptor, Transcription factor, Receptor
01
Overview
Retinoic acid receptor gamma (RAR-γ), also known as NR1B3, is a member of the nuclear receptor superfamily. It functions as a ligand-dependent transcription factor, regulating gene expression by forming heterodimers with RXRs and binding to RAREs. RAR-γ plays critical roles in development, skeletal growth, cell differentiation, and other biological processes. It is a therapeutic target for conditions like acne, and mutations/rearrangements are associated with certain leukemias.
- Other names
- NR1B3Nuclear receptor subfamily 1 group B member 3
02
Mechanism of action
Ligand-dependent transcription factor; forms heterodimers with RXRs and binds to retinoic acid response elements (RAREs) to regulate gene expression.
03
Biological functions
Transcription regulationLimb bud developmentSkeletal growthMatrix homeostasisGrowth plate functionCell differentiationCell proliferationApoptosisStem cell self-renewal/differentiation balanceHormone-mediated signalingResponse to leukemia inhibitory factor
04
Disease associations
AcneLeukemiaOther
05
Safety considerations
Mutations or rearrangements involving RARG have been implicated in certain leukemias resistant to standard therapies such as ATRA.
06
Interacting drugs
Adapalene
2 more in the full profile.
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