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Target intelligence / Profile preview
Retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt)
- Target
- RORγt
- Molecular classification
- Nuclear hormone receptor, Transcription factor
01
Overview
Retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt) is a transcription factor and a member of the nuclear receptor family, encoded by the RORC gene. It is an isoform of RORγ, primarily expressed in immune cells, especially T helper 17 (Th17) cells and certain innate lymphoid cells (ILC3s). It is essential for thymocyte survival during T cell development and acts as a master regulator for Th17 lineage specification, inducing the expression of signature cytokines such as IL-17A and IL-17F. RORγt is a central driver of autoimmune pathologies mediated by pathogenic Th17 responses and is considered an attractive drug target for autoimmune and inflammatory conditions.
- Other names
- RORC2
02
Mechanism of action
RORγt inhibition
03
Biological functions
T cell developmentTh17 differentiationRegulation of gene expressionImmune responseCircadian rhythm regulation
04
Disease associations
AutoimmunityInflammationMultiple sclerosisPsoriasisInflammatory bowel disease
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