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Target intelligence / Profile preview
Retinoic acid receptor-related orphan nuclear receptor gamma truncated (RORγt)
- Target
- RORγt
- Molecular classification
- Nuclear hormone receptor, Transcription factor, Receptor, NR1F3
01
Overview
RORγt is an isoform of RORγ, a member of the nuclear receptor superfamily. It is a master regulator of Th17 cell differentiation and IL-17 production, playing a critical role in immune responses. Dysregulation of RORγt contributes to autoimmune diseases, making it a therapeutic target for conditions like rheumatoid arthritis, multiple sclerosis, and psoriasis. Small molecule inhibitors targeting RORγt are under development.
02
Mechanism of action
Small molecule inhibitors targeting orthosteric or allosteric sites of RORγt to suppress Th17-mediated inflammation
03
Biological functions
Regulation of Th17 cell differentiationRegulation of IL-17 productionImmune responseTranscriptional regulation
04
Disease associations
Rheumatoid arthritisMultiple sclerosisPsoriasisInflammatory bowel diseaseAutoimmune diseases
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