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Target intelligence / Profile preview
Retinoic Acid Receptor-Related Orphan Receptor Gamma (RORγ)
- Target
- RORγ
- Molecular classification
- Nuclear receptor, Transcription factor
01
Overview
RORγ is a nuclear receptor and transcription factor that plays a critical role in immune regulation, metabolism, and circadian rhythm. It is a master regulator of Th17 cell differentiation and is implicated in the pathogenesis of autoimmune diseases. RORγ is also involved in the development of lymph nodes and Peyer’s patches, and regulates circadian genes. Due to its druggability, it is an emerging target for autoimmune diseases and cancer immunotherapy.
- Other names
- RORCRAR-related orphan receptor CNR1F3
02
Mechanism of action
Agonism or inverse agonism of RORγ to modulate gene transcription related to immune responses, metabolism, and circadian rhythm.
03
Biological functions
Immune regulationMetabolismCircadian rhythmRegulation of transcriptionTh17 cell differentiationLymphoid organogenesis
04
Disease associations
Autoimmune diseasesPsoriasisMultiple sclerosisRheumatoid arthritisImmunodeficiencyCancer
05
Safety considerations
Potential for immune dysregulationOff-target effects due to broad tissue distribution
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