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Target intelligence / Profile preview
Retinoic acid-related orphan receptor gamma (RORγ)
- Target
- RORγ
- Molecular classification
- Nuclear receptor, Transcription factor, NR1 subfamily
01
Overview
Retinoic acid-related orphan receptor gamma (RORγ) is a nuclear receptor transcription factor that plays a crucial role in immune system development, circadian rhythm regulation, and metabolic functions. It is essential for Th17 cell differentiation and IL-17 production, making it a key target for autoimmune diseases. RORγ also regulates genes involved in lipid and carbohydrate metabolism, impacting metabolic disorders. The protein possesses a DNA-binding domain and a ligand-binding domain that can be targeted by agonists and inverse agonists to modulate its activity. Its expression is widespread, including immune cells, liver, adipose tissue, skeletal muscle, and kidney.
- Other names
- RORCRAR-related orphan receptor C
02
Mechanism of action
Agonist or inverse agonist binding to the ligand-binding domain, modulating transcriptional activity.
03
Biological functions
Transcriptional regulationImmune responseCircadian rhythm regulationLipid homeostasisCarbohydrate metabolismMuscle mass maintenance
04
Disease associations
Autoimmune diseasesCancerMetabolic disorders
05
Safety considerations
Potential for broad effects due to widespread tissue distributionImmunosuppressionAltered lipid/glucose metabolism
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