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Target intelligence / Profile preview
Retinoic Acid-Related Orphan Receptor Gamma t (RORγt)
- Target
- RORγt
- Molecular classification
- Nuclear receptor, Transcription factor, Ligand-dependent transcription factor
01
Overview
Retinoic acid-related orphan receptor gamma t (RORγt) is a member of the nuclear receptor superfamily and a ligand-dependent transcription factor. It is a key regulator of Th17 cell differentiation and function, driving the expression of pro-inflammatory cytokines. RORγt is implicated in various autoimmune diseases and potentially in cancer. It is considered a druggable target with both orthosteric and allosteric ligand binding sites. The RORC gene encodes two isoforms: RORγ and RORγt, with RORγt being selectively expressed in immune tissues.
- Other names
- RORC2RAR-related orphan receptor gamma t
02
Mechanism of action
Binds specific DNA response elements as a monomer or dimer to activate or repress gene transcription, depending on ligand binding status and cellular context. Ligand binding induces conformational changes affecting coactivator/corepressor recruitment at target gene promoters/enhancers.
03
Biological functions
Immune regulationTh17 cell differentiationCircadian rhythm regulationLipid metabolismGlucose metabolismGene transcription regulation
04
Disease associations
Autoimmune diseasesMultiple sclerosisRheumatoid arthritisInflammatory bowel diseasePsoriasisCancer
05
Safety considerations
Therapeutically targeting RORγt may modulate pathogenic Th17 responses but could also risk destabilizing lineage fidelity or promoting unwanted TH2 conversion if not carefully controlled.
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