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Target intelligence / Profile preview
Retinoid Nuclear Receptor Pathway (Retinoid Pathway)
- Target
- Retinoid Pathway
- Molecular classification
- Signaling pathway
01
Overview
The retinoid nuclear receptor pathway is a signaling cascade mediated by RAR and RXR nuclear receptors, activated by retinoids (vitamin A derivatives). It regulates gene expression, influencing development, cell fate, immunity, and metabolism. Dysregulation is linked to various diseases, including cancer, metabolic disorders, and developmental abnormalities. The pathway is considered a signaling pathway, not a direct therapeutic target, because drugs target the receptors within the pathway.
- Other names
- Vitamin A signaling pathwayRetinoic acid signaling pathwayRXR/RAR pathway
02
Mechanism of action
Ligand-dependent activation of RAR/RXR heterodimers, leading to altered gene transcription
03
Biological functions
DevelopmentCell growthCell differentiationApoptosisImmune responseMetabolismGene regulationTranscription regulation
04
Disease associations
CancerMetabolic disordersSkin conditionsDevelopmental abnormalities
05
Safety considerations
TeratogenicityHypervitaminosis ASkin irritationMucous membrane dryness
06
Interacting drugs
All-trans-retinoic acid (ATRA)
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